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5 Research and evaluate any known potential pharmacokinetic and pharmacodynamic herb- drug interactions;
6 Evaluate the potential severity and level of evidence of an interaction by using the ratings, such as those included in Natural Medicines Comprehensive Database (insignificant, mild, moderate and high);
7 Adjust herbal formula by using substitute herb(s) or deleting the suspected herb(s) that are known to cause clinically significant interactions;
8 Monitor the patient closely when potential herb- drug interactions are not clinically significant or very mild (blood drug concentration may be affected, but a clinical significant interaction is not likely, or the interaction may cause only mild impairment or mild discomfort); and
9 Adjust formula further if necessary.
9. Qang Qibin, Di Wei, Cheng Xiaoli, et al., Effect of Puerarin on the Activities of CYP450 in Vitro, Herald of Medicine 2008 27 (5) 500-504 10. Li Zhuo, Li xinming, Wang Haiyun, et al., Effect of Crude Extract of Scutellarla Barbata D. don on the activities of cyp450 in human liver microsomes, Central South Pharmacy, 2006 6(1) 53-55
11. Henderson GL, Harkey MR., Gershwin ME., et al, Effects of Gingseng Components on c-DNA- expression cytochrome p450 enzyme catalytic activity, Life Science, 1999, 65(15);209-241
12. Subehan, Usia, T., Kadota, S., Tezuka, Y., Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity, Chemical & Pharmaceutical Bulletin (Tokyo). 2005 Mar; 53(3):333-5)
13. Subehan, Tepy Usia, Hiroshi Iwata, Shigetoshi Kadota and Yasuhiro Tezuka, Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants, Journal of Ethnopharmacology Volume 105, Issue 3, 24 May 2006, 449-455)
14. Iwata H, Inhibitory of 78 Herbal Extracts on Human Liver Cells CYP3A4 and CYP2D6, J Trad Med. 2004, 21 (1) 42-50, (Chinese Translation)
15. Iwata H, Inhibitory Effect of 26 Herbal Methanol Extracts on Human Liver Cells CYP3A4 and CYP2D6, J Trad Med. 2004, 21 (6) 281-286, (Chinese Translation
16. Yang Jing, Peng Ren, Kong Rui, et al, EFFECTS OF 18α-GLYCYRRHIZIC ACID ON RAT LIVER CYTOCHROME P450 ISOENZYMES AND PHASE II TRANSFERASE ACTA PHARMACEUTICA SINICA 2001 (5)
17. The Effect of Berberine Hydrochloride and Cyclosporin A on CYP3A2 of mice liver and small intestine, CHINESE PHARMACEUTICAL JOURNAL, 2005 40(5) 18. Hiroshi Iwata, et al Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract, Drug metabolism and disposition: the biological fate of chemicals. 01/01/2005; 32(12):1351-8.
19. (Iwata Hiroshi, Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract, Drug metabolism and pharmacokinetics. 03/2005; 20(1):34-45.
20. Usia T, Iwat H, Hiratsuka A, et al, Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities,Journal of natural products. 08/2004; 67(7):1079-83.
21. Tepy Usia, Tadashi Watabe, Shigetoshi Kadota, and Yasuhiro Tezuka, Potent CYP3A4 Inhibitory Constituents of Piper cubeba J. Nat. Prod., 2005, 68 (1), pp 64–68)
22. Subehan, Tepy Usia, Hiroshi Iwata, Shigetoshi Kadota and Yasuhiro Tezuka, Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants, Journal of Ethnopharmacology Volume 105, Issue 3, 24 May 2006, 449-455
23. YANG Xiufen;WANG Naiping;ZENG Fandian , et al, Effects of ginkgolides on gene
Reference
1. Eisenberg DM, Davis RB, Ettner SL, et al.Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998; 280:1569-1575. 2. Barnes PM, Powell-Griner E, McFann K, Nahin RL (May 2004). "Complementary and alternative medicine use among adults: United States, 2002". Advance Data (343): 1–19. PMID 15188733. http://www.cdc.gov/nchs/ data/ad/ad343.pdf.
3. http://zhidao.baidu.com/question/ 149632507.html?push=related (in Chinese)
4. Greg Sperber and Bob Flaws, Integrated Pharmacology, Page 22, Blue Poppy Press, 2007
5. Yuan, Bojun and Gu, Changhong Analysis of 484 Death Cases Related to the Toxicity of Chinese Herbs, Journal of Chinese New Drug and Pharmacology, 1992 8(3) (Chinese)
6. Michael D. Coleman, Human Drug Metabolism May 2006,
7. Cytochrome P450 Drug Interaction Table, School of Medicine, Indiana University, www.drug-interactions.com
8. Furong Qiu, et al., Inhibitory Effects of Seven Components of Danshen Extract on Catalytic ActivityDrug Metab Dispos.2008; 36: 1308-1314)
DIALOGHIDIMEDICINAINTEGRATA estate 2017